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CryoSPARC
new Cryo em tooL
CryoSPARC (Cryo-EM Single Particle Ab-Initio Reconstruction and Classification) is a scientific software platform for cryo-electron microscopy (cryo-EM). It was created to facilite a fast, accurate and automated solution to scientists working on drug discovery or pharmaceutical areas. Cryosparc combines powerful innovations in 3D reconstruction algorithms with a streamlined end-to-end single particle cryo-EM workflow to process image data in minutes on powerful GPU computers.
This software can rapidly solve high-resolution structures of biological important targets. So generally is used for solving cryo-EM structures of membrane proteins, viruses, complexes, flexible molecules, small particles, phase plate data and negative stain data.
latest VERSION: CRYOSPARC V4.2.1
Launched on March 2021, Cryosparc v4.2.1 is the latest release of this popular software. It includes new features, performance optimizations and various stability improvements. Some of these highlights are:
- NEW. A project-level parameter now controls whether or not jobs output intermediate results, with default on. Turning this off will save disk space, without having to manually clear intermediate results after the jobs complete.
- Ultra-fast end-to-end processing of raw cryo-EM data and reconstruction of electron density maps, ready for ingestion into model building software.
- Optimized algorithms and GPU acceleration at all stages, from pre-processing through particle picking, 2D particle classification, 3D ab-initio structure determination, high resolution refinement, and heterogeneity analysis.
- Specialized and unique tools for therapeutically relevant targets, membrane proteins, continuously flexible structures.
- Interactive, visual and iterative experimentation for even the most complex workflows.
- User-friendly computer program.
Image: Molecular structure reconstruction made with cryo-EM techniques.
Official Cryosparc web page.
NOTE:
Cryosparc was developed by Structura Biotechnology Inc and it is available free of charge
for non-profit academic use, but it is necessary to have a license.
If you are interested in using CryoSPARC, we can get the license and install this software for you in our GPU supercomputers