CryoSPARC (Cryo-EM Single Particle Ab-Initio Reconstruction and Classification) is a scientific software platform for cryo-electron microscopy (cryo-EM). It was created to facilite a fast, accurate and automated solution to scientists working on drug discovery or pharmaceutical areas. Cryosparc combines powerful innovations in 3D reconstruction algorithms with a streamlined end-to-end single particle cryo-EM workflow to process image data in minutes on powerful GPU computers.
This software can rapidly solve high-resolution structures of biological important targets. So generally is used for solving cryo-EM structures of membrane proteins, viruses, complexes, flexible molecules, small particles, phase plate data and negative stain data.