The new functionality in Relion 3.1 allows faster, more automated and higher resolution cryo-EM structure determination compared to previous versions. GPU acceleration makes it possible to use a much wider range of hardware efficiently for Relion.
Corrections for per-particle defocus variations, beam tilt and the Ewald sphere already improve resolutions for currently available data sets, and will become even more important as the resolutions of typical cryo-EM structures improve in the future.