Relion Cryo EM

CRYO EM SOFTWARE

RELION is an image processing software designed specifically for Cryo-electron Microscopy (cryo-EM). It is a stand-alone computer program built for the refinement of macromolecular structures by single-particle analysis of electron cryo-microscopy data. Developed by the group of Sjors Scheres at the MRC Laboratory of Molecular Biology, this framework is revolutionizing the cryo-EM field.

Relion employs an empirical Bayesian approach for refinement of multiple 3D reconstructions or 2D class averages. With alternative approaches often relying on user expertise for the tuning of parameters, it can find an optimal way of filtering the data automatically.

NEW RELION 3.1

The new functionality in RELION 3.1 allows faster, more automated and higher resolution cryo-EM structure determination compared to Relion 3.0 and other previous versions.

Macromolecular structure determination by single-particle analysis cryo-em images has experienced rapid progress in recent years. This new release allows a better GPU acceleration and a much wider range of hardware efficiently. These are some of the major changes.

High-order aberration correction and anisotropic magnification correction in CTF refinement.
External jobtype to run third-party software in the Relion pipeline.
Schedules for designing and executing on-the-fly processing procedures.
Tweaks to GUI, pipeliner and helical processing.
Symmetry relaxation.

Image: Enzyme structure observed with cryo-em techniques.

Carlos Fernández-Tornero y Marta Sanz-Murillo (CIB Margarita Salas – CSIC)

For those interested in Cryo-electron microscopy full turnkey solutions, here you can find our GPU Workstations and Servers

We offer also maintenance services for Cryo EM systems